Introduction to Transdermal Drug Delivery

In this blog, I will be talking about an overview and introduction of my current research which is about transdermal drug delivery. Transdermal drug delivery is basically the delivery of drugs through the skin. How can transdermal drug delivery be better compared to the conventional methods?

Two most common types of drug delivery exploited currently are oral and intravenous administrations. However, transdermal drug delivery, the delivery of drugs through the skin, is becoming a more acceptable and favorable alternative to these methods because it does not cause pain that injections offer and it also reduces side effects of oral medications. Because it uses the skin as the direct route to deliver drugs, it can prevent passing through the gastrointestinal tract, making the drug more effective and efficient. Even though transdermal drug delivery can offer more advantages, it still poses a big challenge since the skin’s main purpose is to protect the body from the outside environment. Currently, transdermal drugs contain molecules that are small enough to pass through the skin. But how about other bigger and more important drugs like insulin? Unfortunately, this is one of the challenges that transdermal drug delivery is trying to surpass. In conclusion, the size, polarity, and charge of the drug molecule are the main factors that affect skin penetration.


Jordanne Gregorio is third year student majoring in Chemical Engineering. She is interested in research relating to medicine and pharmaceuticals and is currently working in Professor Samir Mitragotri’s lab this year quarter.

Posted in 2010-2011, EUREKA

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